An excerpt from the humorous Late Show with David Letterman. Jokes in the show are based on pop culture, current events, and politics.
In this particular part, they mention the popular show Grey's Anatomy. The main character, Meredith Grey, is known for her subtle sense of humor. She often gives people nicknames. She calls Dr. Derek Shepherd, McDreamy, as probably the next "dreamy" guy to come along in her life. Meredith was the one who also came up with the name "McSteamy" for Dr Sloan who is Derek's good friend and really hot, too.
Watch the video and see how David Letterman uses this joke to make fun of some famous people.
Do you recognize their faces? Why do you think they gave them those nicknames?